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Held for a period of three days, History of Restriction Enzyme can be defined as a great conference which will take place in Cold Spring Harbor Laboratory, New York, USA. It is going to be hosted by the CSHL Genentech Center for the History of Molecular Biology and Biotechnology and the main podium is going to talk about enzymes that cleave DNA at specific recognition sites. There are over 3,000 restriction enzymes are known today, of which more than 625 are commercially available and those are going to be discussed here in this conference namely History of Restriction Enzyme. It is also going to talk about the history of these enzymes.