Every season in the NFL produces performances that feel less like a single game and more like statistical outliers — explosive outings where quarterbacks pile up passing yards, running backs break off long scoring runs, and receivers turn routine targets into multi-touchdown afternoons. These are the kinds of games that separate good fantasy weeks from historic ones.
Stacker compiled a ranking of the best Buffalo Bills fantasy performances from 2016 to 2025 using data from Stathead. The list includes the highest single-game fantasy scores by quarterbacks, running backs, wide receivers, and tight ends. Players are ranked based on standard fantasy scoring.
Best quarterback fantasy games
#10. Josh Allen, December 19, 2020
- Stats: 359 Passing Yards, 2 Passing TDs, 0 Interceptions, 33 Rushing Yards, 2 Rushing TDs
- Game: BUF vs DEN, 48-19 Win
- Fantasy points: 37.66
#9. Josh Allen, December 7, 2025
- Stats: 251 Passing Yards, 3 Passing TDs, 0 Interceptions, 78 Rushing Yards, 1 Rushing TDs
- Game: BUF vs CIN, 39-34 Win
- Fantasy points: 37.84
#8. Josh Allen, January 23, 2022
- Stats: 329 Passing Yards, 4 Passing TDs, 0 Interceptions, 68 Rushing Yards
- Game: BUF vs KAN, 36-42 (OT) Loss
- Fantasy points: 37.96
#7. Josh Allen, September 7, 2025
- Stats: 394 Passing Yards, 2 Passing TDs, 0 Interceptions, 30 Rushing Yards, 2 Rushing TDs
- Game: BUF vs BAL, 41-40 Win
- Fantasy points: 38.76
#6. Josh Allen, January 15, 2022
- Stats: 308 Passing Yards, 5 Passing TDs, 0 Interceptions, 66 Rushing Yards
- Game: BUF vs NWE, 47-17 Win
- Fantasy points: 38.92
#5. Josh Allen, November 26, 2023
- Stats: 339 Passing Yards, 2 Passing TDs, 1 Interceptions, 81 Rushing Yards, 2 Rushing TDs
- Game: BUF vs PHI, 34-37 (OT) Loss
- Fantasy points: 39.66
#4. Josh Allen, December 30, 2018
- Stats: 224 Passing Yards, 3 Passing TDs, 1 Interceptions, 95 Rushing Yards, 2 Rushing TDs
- Game: BUF vs MIA, 42-17 Win
- Fantasy points: 40.46
#3. Josh Allen, December 15, 2024
- Stats: 362 Passing Yards, 2 Passing TDs, 0 Interceptions, 68 Rushing Yards, 2 Rushing TDs
- Game: BUF vs DET, 48-42 Win
- Fantasy points: 41.28
#2. Josh Allen, November 16, 2025
- Stats: 317 Passing Yards, 3 Passing TDs, 2 Interceptions, 40 Rushing Yards, 3 Rushing TDs
- Game: BUF vs TAM, 44-32 Win
- Fantasy points: 42.68
#1. Josh Allen, December 8, 2024
- Stats: 342 Passing Yards, 3 Passing TDs, 0 Interceptions, 82 Rushing Yards, 3 Rushing TDs
- Game: BUF vs LAR, 42-44 Loss
- Fantasy points: 51.88
Best running back fantasy games
#10. James Cook, December 21, 2025
- Stats: 117 Rushing Yards, 2 Rushing TDs, 17 Receiving Yards
- Game: BUF vs CLE, 23-20 Win
- Fantasy points: 25.4
#9. James Cook, January 26, 2025
- Stats: 85 Rushing Yards, 2 Rushing TDs, 49 Receiving Yards
- Game: BUF vs KAN, 29-32 Loss
- Fantasy points: 25.4
#8. James Cook, September 14, 2025
- Stats: 132 Rushing Yards, 2 Rushing TDs
- Game: BUF vs NYJ, 30-10 Win
- Fantasy points: 25.5
#7. LeSean McCoy, November 27, 2016
- Stats: 103 Rushing Yards, 2 Rushing TDs, 31 Receiving Yards
- Game: BUF vs JAX, 28-21 Win
- Fantasy points: 27.4
#6. James Cook, September 12, 2024
- Stats: 78 Rushing Yards, 2 Rushing TDs, 17 Receiving Yards, 1 Receiving TDs
- Game: BUF vs MIA, 31-10 Win
- Fantasy points: 27.5
#5. LeSean McCoy, December 18, 2016
- Stats: 153 Rushing Yards, 2 Rushing TDs, 16 Receiving Yards
- Game: BUF vs CLE, 33-13 Win
- Fantasy points: 28.9
#4. James Cook, December 14, 2025
- Stats: 107 Rushing Yards, 2 Rushing TDs, 1 Receiving TDs
- Game: BUF vs NWE, 35-31 Win
- Fantasy points: 29.1
#3. LeSean McCoy, October 16, 2016
- Stats: 140 Rushing Yards, 3 Rushing TDs
- Game: BUF vs SFO, 45-16 Win
- Fantasy points: 32.2
#2. James Cook, October 26, 2025
- Stats: 216 Rushing Yards, 2 Rushing TDs
- Game: BUF vs CAR, 40-9 Win
- Fantasy points: 33.6
#1. James Cook, December 17, 2023
- Stats: 179 Rushing Yards, 1 Rushing TDs, 42 Receiving Yards, 1 Receiving TDs
- Game: BUF vs DAL, 31-10 Win
- Fantasy points: 34.1
Best wide receiver fantasy games
#10. Sammy Watkins, December 24, 2016
- Stats: 154 Receiving Yards, 1 Receiving TDs, 7 Receptions, 10 Targets
- Game: BUF vs MIA, 31-34 (OT) Loss
- Fantasy points: 21.4
#9. Emmanuel Sanders, September 26, 2021
- Stats: 94 Receiving Yards, 2 Receiving TDs, 5 Receptions, 6 Targets
- Game: BUF vs WAS, 43-21 Win
- Fantasy points: 21.4
#8. Stefon Diggs, November 14, 2021
- Stats: 162 Receiving Yards, 1 Receiving TDs, 8 Receptions, 13 Targets
- Game: BUF vs NYJ, 45-17 Win
- Fantasy points: 22.2
#7. Isaiah McKenzie, January 3, 2021
- Stats: 65 Receiving Yards, 2 Receiving TDs, 6 Receptions, 9 Targets
- Game: BUF vs MIA, 56-26 Win
- Fantasy points: 24.5
#6. John Brown, November 17, 2019
- Stats: 137 Receiving Yards, 2 Receiving TDs, 9 Receptions, 14 Targets
- Game: BUF vs MIA, 37-20 Win
- Fantasy points: 25.7
#5. Gabe Davis, October 9, 2022
- Stats: 171 Receiving Yards, 2 Receiving TDs, 3 Receptions, 6 Targets
- Game: BUF vs PIT, 38-3 Win
- Fantasy points: 29.1
#4. Stefon Diggs, October 1, 2023
- Stats: 120 Receiving Yards, 3 Receiving TDs, 6 Receptions, 7 Targets
- Game: BUF vs MIA, 48-20 Win
- Fantasy points: 30.0
#3. Stefon Diggs, December 28, 2020
- Stats: 145 Receiving Yards, 3 Receiving TDs, 9 Receptions, 11 Targets
- Game: BUF vs NWE, 38-9 Win
- Fantasy points: 32.5
#2. Stefon Diggs, September 19, 2022
- Stats: 148 Receiving Yards, 3 Receiving TDs, 12 Receptions, 15 Targets
- Game: BUF vs TEN, 41-7 Win
- Fantasy points: 32.8
#1. Gabe Davis, January 23, 2022
- Stats: 201 Receiving Yards, 4 Receiving TDs, 8 Receptions, 10 Targets
- Game: BUF vs KAN, 36-42 (OT) Loss
- Fantasy points: 44.1
Best tight end fantasy games
#10. Dalton Kincaid, January 17, 2026
- Stats: 83 Receiving Yards, 1 Receiving TDs, 6 Receptions, 6 Targets
- Game: BUF vs DEN, 30-33 (OT) Loss
- Fantasy points: 14.3
#9. Tyler Kroft, September 27, 2020
- Stats: 24 Receiving Yards, 2 Receiving TDs, 4 Receptions, 5 Targets
- Game: BUF vs LAR, 35-32 Win
- Fantasy points: 14.4
#8. Dawson Knox, November 25, 2021
- Stats: 32 Receiving Yards, 2 Receiving TDs, 3 Receptions, 3 Targets
- Game: BUF vs NOR, 31-6 Win
- Fantasy points: 15.2
#7. Dawson Knox, October 3, 2021
- Stats: 37 Receiving Yards, 2 Receiving TDs, 5 Receptions, 8 Targets
- Game: BUF vs HOU, 40-0 Win
- Fantasy points: 15.7
#6. Dawson Knox, December 14, 2025
- Stats: 37 Receiving Yards, 2 Receiving TDs, 3 Receptions, 4 Targets
- Game: BUF vs NWE, 35-31 Win
- Fantasy points: 15.7
#5. Dawson Knox, December 17, 2022
- Stats: 98 Receiving Yards, 1 Receiving TDs, 6 Receptions, 8 Targets
- Game: BUF vs MIA, 32-29 Win
- Fantasy points: 15.8
#4. Dalton Kincaid, November 2, 2025
- Stats: 101 Receiving Yards, 1 Receiving TDs, 6 Receptions, 6 Targets
- Game: BUF vs KAN, 28-21 Win
- Fantasy points: 16.1
#3. Dawson Knox, October 10, 2021
- Stats: 117 Receiving Yards, 1 Receiving TDs, 3 Receptions, 4 Targets
- Game: BUF vs KAN, 38-20 Win
- Fantasy points: 17.7
#2. Charles Clay, December 24, 2016
- Stats: 85 Receiving Yards, 2 Receiving TDs, 8 Receptions, 10 Targets
- Game: BUF vs MIA, 31-34 (OT) Loss
- Fantasy points: 20.5
#1. Dawson Knox, January 15, 2022
- Stats: 89 Receiving Yards, 2 Receiving TDs, 5 Receptions, 5 Targets
- Game: BUF vs NWE, 47-17 Win
- Fantasy points: 20.9